Synonyms: VATER sequence, VATER association, VACTEL syndrome
Definition:Association of malformations including V (vertebral anomalies), A (anal atresia), C (cardiac anomalies), TE (tracheoesophageal fistula or esophageal atresia), R (renal/urinary anomalies), L (limb defect)
What The Referring Physician Needs To Know- Patients are considered to have VACTERL association when three or more organ systems are involved
- Differential diagnosis: Townes syndrome, trisomy 18, trisomy 13, other disorders characterized by vertebral, renal, radial defects
- Termination of pregnancy can be offered before viability
- Monthly sonographic monitoring of fetal growth, evaluation of structural defects are recommended
- Delivery in tertiary center is required for prompt surgical repair and rehabilitation
- Neonates with VACTERL association should remain on antibiotic prophylaxis for urinary tract infection while awaiting completion of screening
- Urologic follow-up is crucial since majority of patients eventually require genitourinary intervention
